Nucleocapsid Assembly and Envelopment of Herpes Simplex Virus
Joel D. Baines and Carol Duffy
from: Alpha Herpesviruses: Molecular and Cellular Biology (Edited by: R. M. Sandri-Goldin). Caister Academic Press, U.K. (2006)
Herpes simplex virus capsids assemble in the nuclei of infected cells in a number of ordered steps. The spherical procapsid is the first capsid formed and consists of an inner and outer shell. Proteolytic cleavage of the inner capsid shell, followed by subsequent expulsion or degradation of the inner shell and insertion of genomic DNA, results in a dramatic conformational change in which the outer shell of the procapsid angularizes and matures into a stable icosahedron. The completed, DNA-filled nucleocapsid is then actively transported to the nuclear membrane where it attaches and buds into the perinuclear space to become a virion. These events are detailed in the following review read more ...