Hailing the Arrival of the Messenger: Strategies for Translational Control in Herpes Simplex Virus-infected Cells
from: Alpha Herpesviruses: Molecular and Cellular Biology (Edited by: R. M. Sandri-Goldin). Caister Academic Press, U.K. (2006)
Like all viruses, the translation of a-herpesvirus mRNAs relies completely upon components in their host cells. Thus, ensuring that viral mRNAs are able to effectively engage cellular translation factors and compete with cellular mRNAs for access to this equipment is of paramount importance. Notwithstanding the onslaught of a potent cellular antiviral response focused on incapacitating the translation machinery, the significance of viral protein production is further accentuated by viral functions devoted to neutralizing this host retort and preserving the activity of the host translational apparatus. Here, interactions between a-herpesviruses, exemplified by herpes simplex virus-1, with host translation initiation factors are discussed and recent developments concerning how viral functions control translation in infected cells are presented read more ...