New Developments on the Virulence Mechanisms of Aeromonas hydrophila
Elena V. Kozlova, Duraisamy Ponnusamy, and Ashok K. Chopra
from: Aeromonas (Edited by: Joerg Graf). Caister Academic Press, U.K. (2015) Pages: 139-154.
This chapter covers new virulence factors/mechanisms that are associated with infections caused by Aeromonas species. We focused primarily on the type 3 secretion system (T3SS) effector AexU, which has ADP-ribosyltransferase and GTPase-activating protein activities and operates by inhibiting NF-κB in the host cells. Emphasis was also placed on the T6SS and its effectors Hemolysin coregulated protein (Hcp) and Valine-glycine-repeat G (VgrG) family protein members in terms of their roles in the pathogenesis of Aeromonas infections. While Hcp inhibits bacterial phagocytosis, VgrG1 through its carboxyl-terminal vegetative insecticidal protein-2 (VIP-2) domain, leads to ADP ribosylation of host cell actin, thus preventing its polymerization and cytotoxicity in the eukaryotic cells. Finally, the role is discussed of three quorum-sensing systems (AI-1-AI-3) in modulating bacterial virulence through second messenger cyclic-diguanylate monophosphate (c-di-GMP) read more ...