Caister Academic Press

Acanthamoeba infections

from: Acanthamoeba: Biology and Pathogenesis (2nd edition) (Author: Naveed Ahmed Khan). Caister Academic Press, U.K. (2015) Pages: 117-152.

Abstract

1. Acanthamoeba keratitis
1.1. Acanthamoeba binding to worn and unworn contact lenses
1.2. Biofilm formation
1.3. Corneal injury
1.4. Epidemiology
1.5. Pathophysiology
1.6. Is Acanthamoeba keratitis limited to cornea?
1.7. Why is it so painful?
1.8. Diagnosis of Acanthamoeba keratitis
1.8.1. Clinical diagnosis
1.8.2. Laboratory identification and differentiation of Acanthamoeba spp.
1.8.3. Culture of Acanthamoeba
1.8.4. Microscopic identification based on morphological characteristics
1.8.5. Isoenzyme analysis
1.8.6. Antibody-based assays
1.8.6.1. Immunofluorescence assays
1.8.6.2. Flow cytometry
1.8.7. Cellulose-based identification
1.8.8. Polymerase chain reaction
1.8.9. Matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS)
1.8.10. High-resolution ¹H nuclear magnetic resonance (NMR) spectroscopy in the clinical diagnosis of Acanthamoeba
1.9. T4 genotype is the predominant cause of keratitis and encephalitis
1.10. Host susceptibility
1.11. Species specificity
1.12. Risk factors
1.13. Treatment
1.13.1. Cryosurgery
1.13.2. Chemotherapy
1.13.3. Systemic administration of antimicrobials against stromal Acanthamoeba keratitis
2. Granulomatous amoebic encephalitis due to Acanthamoeba
2.1. Routes of entry into the central nervous system
2.2. Epidemiology
2.3. Pathophysiology of granulomatous ameobic encephalitis due to Acanthamoeba
2.4. Diagnosis: Clinical and laboratory diagnosis
2.5. Host susceptibility
2.6. Species and organ specificity
2.7. Risk factors
2.8. Treatment
2.8.1. Can anesthesia choice affect the clinical outcome of granulomatous amoebic encephalitis due to Acanthamoeba spp.?
3. Cutaneous Acanthamebiasis
4. Multiple sclerosis and Acanthamoeba
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