Strategies against Acanthamoeba infections
from: Acanthamoeba: Biology and Pathogenesis (Author: Naveed Khan). Caister Academic Press, U.K. (2009)
Abstract
• Chemotherapeutic agents and Acanthamoeba
• Membrane-acting agents
Polyhexamethylene biguanide
Chlorhexidine digluconate
Acriflavine hydrochloride
Phospholipid analogues
Polymyxin B
Polymyxin E (colistin)
Caspofungin
Ergosterol biosynthesis
Ketoconazole
Miconazole
Clotrimazole
Fluconazole
Amphotericin B
Benzimidazole and Benzotriazole
• Inhibitors of DNA synthesis and polyamine metabolism
Diamidine derivatives
Methylglyoxal bis (guanyl hydrazone) (MGBG)
Berenil
Myristamidopropyl dimethylamine (MAPD)
Folate biosynthesis inhibitors
• RNA synthesis inhibitors
Rifampicin
5-fluorocytosine
• Protein synthesis inhibitors
Macrolide compounds
Rokitamycin
Spiramycin
Aminoglycosides
Paromomycin
Neomycin
Neosporin
N-chlorotaurine
• Tricyclic neuroleptic agents (calmodulin inhibition)
Trifluoperazine dihydrochloride and chlorpromazine dihydrochloride (phenothiazine compound)
• Artesunate
• Antimicrobial compounds from natural products
Animal-based natural products
Magainins
Plant-based natural products
• Drug resistance in Acanthamoeba
• Disinfectants and Acanthamoeba
Disinfection agents
Freeze-thaw
Heat disinfection
Microwave irradiation
Ultraviolet light irradiation
Gamma irradiation
• Future prospects for treatment
Antibody-based therapy
Using a carrier for drug delivery
Use of a liposome for drug delivery
Photodynamic chemotherapy against Acanthamoeba
Photo-inhibition of Acanthamoeba
Use of photosensitizer against Acanthamoeba
