Caister Academic Press

Acanthamoeba infections

from: Acanthamoeba: Biology and Pathogenesis (Author: Naveed Khan). Caister Academic Press, U.K. (2009)

Abstract

• Human infections
Acanthamoeba keratitis
Binding to worn and unworn contact lenses
Biofilm formation
Corneal injury
Epidemiology
Pathophysiology
Is Acanthamoeba keratitis limited to cornea
Why is it so painful?
Diagnosis
Clinical diagnosis
Laboratory identification and differentiation of Acanthamoeba spp.
Culture of Acanthamoeba
Microscopic identification based on morphological characteristics
Isoenzyme analysis
Antibody-based assays
Immunofluorescence assays
Flow cytometry
Polymerase chain reaction
Matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS)
T4 genotype is the predominant cause of keratitis and granulomatous amoebic encephalitis
Host susceptibility
Species specificity
Risk factors
Treatment
Cryosurgery
Chemotherapy
• Granulomatous amoebic encephalitis
Routes of entry into the central nervous system
Epidemiology
Pathophysiology of granulomatous amoebic encephalitis
Diagnosis
Clinical and laboratory diagnosis
Host susceptibility
Species and organ specificity
Risk factors
Treatment
• Cutaneous Acanthamebiasis
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