Caister Academic Press

Cellular Functions of ABC Proteins in Trypanosomatidae

Philippe Leprohon, Danielle Légaré and Marc Ouellette
from: ABC Transporters in Microorganisms: Research, Innovation and Value as Targets against Drug Resistance (Edited by: Alicia Ponte-Sucre). Caister Academic Press, U.K. (2009)

Abstract

The ATP-binding cassette (ABC) protein superfamily is a ubiquitous and functionally versatile family of proteins that is conserved from archae to man. In eukaryotes, most of these proteins are implicated in the transport of a variety of molecules across cellular membranes, whereas others are involved in biological processes unrelated to transport. ABC proteins have been reported in several parasitic protozoa, including parasites of the Trypanosomatidae family, which gathers evolutionary related protozoa of medical relevance like Leishmania spp., Trypanosoma cruzi and Trypanosoma brucei. A recent survey of the genome sequences of three trypanosomatid parasites indicated the presence of a complete set of ABC genes, with representative members of every subfamily described in eukaryotes (ABCA-ABCH). The biological functions of several members of the ABCA, ABCB, ABCC, ABCE and ABCG subfamilies have been described in protozoan parasites and include vesicular trafficking, phospholipids movement, translation and drug resistance. This chapter will review the ABC proteins that have been described in Trypanosomatidae and will present our current understanding on their functions in the biology of these medically important protozoan parasites read more ...
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