Caister Academic Press

ABC Transporters in Plasmodium falciparum and their Involvement in Resistance to Antimalarial Drugs

Bruno Pradines, Véronique Parquet and Eve Orlandi-Pradines
from: ABC Transporters in Microorganisms: Research, Innovation and Value as Targets against Drug Resistance (Edited by: Alicia Ponte-Sucre). Caister Academic Press, U.K. (2009)

Abstract

Malaria is by far the world's most important parasitic disease. Unfortunately, the extensive use of drugs led to the emergence of drug resistance. Quinoline resistance is associated with decreased accumulation of drugs in intracellular vacuoles, due to reduced drug uptake into the cell, increased efflux from the cell or a combination of both. A number of candidate transporters in P. falciparum, including ABC transporters, such as Pgh1 (PfMDR1) and PfMRP, have been proposed to be involved in antimalarial resistance. Targeting these transport proteins with specific drugs may permit to reverse quinoline resistance. Compounds, belonging to different pharmacological classes have demonstrated in the past decade a promising capability to reverse the antimalarial resistance in vitro of parasite isolates, as well as in animal models and human malaria. Herein we will present the progress made in biochemical and genetic basis of antimalarial resistance, emphasizing the recent developments on drugs, which interfere with transmembrane proteins involved in drug efflux, or uptake read more ...
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