HIV Chemotherapy: A Critical Review | BookPublisher: Caister Academic Press
Edited by: Salvatore T. Butera
National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Pages: x + 310
Publication date: September 2005Buy book
Price: GB £219 or US $319
Since the beginning of the AIDS pandemic in the early 1980's nearly 50 million people have been infected and over 16 million of those have died of AIDS. Combination anti-HIV therapy has dramatically reduced mortality rates and increased life expectancy in infected individuals. However it has not eradicated AIDS: the endemic is merely contained in industrialized nations and continues unabated in developing countries, e.g. Africa and parts of Asia. Since current anti-HIV drugs are virostatic rather than virotoxic, infected individuals must remain on drug therapy for life. This is a major problem since all of the existing anti-HIV drugs have side effects, some of which are serious and potentially fatal. In addition, the naturally occurring and extensive genetic variation found in HIV has led to the emergence of drug-resistant viruses. These challenges have prompted the urgent search for novel, molecular-based drugs and therapeutic strategies that target the different stages of viral infection of and interaction with the host.
This is a book aimed at the scientist in the research laboratory. Written by expert international authors, the book is an essential reference for scientists working on AIDS, HIV and other retroviruses. Expert AIDS researchers critically review every aspect of this highly topical subject. The opening chapters deal with the management of HIV infections and include a fascinating review of current molecular strategies to protect and strengthen the host immune system at the cellular level. Chapters 6 and 7 summarises the strategies required for the implementation of effective anti-HIV therapies in developing countries (90% of worldwide AIDS cases). Two excellent chapters (4 and 5) comprehensively review the genetics of viral drug resistance, and current drug-resistance testing technologies. The remaining chapters provide cutting-edge reviews of the latest viral and cellular targets for anti-HIV chemotherapy, the development of iRNA based therapeutics and molecular based strategies that target latent virus reservoirs in infected individuals.
Essential reading for scientists and clinicians working on AIDS, HIV, and other retroviruses as well as all health care professionals interested in expanding their current understanding of the subject.
"the book provides a useful attribute to all interested in HIV disease and its therapy ... When encountered on the actively employed bookshelves in the HIV / AIDS research laboratory it may be a frequently used source of information." from FEMS Immunol. Med. Microbiol. (2005) Nov/Dec.
"This excellent book is a comprehensive, critical review of aspects of HIV chemotherapy. ... an essential addition to any specialist library." from Microbiology Today (Feb 2006).
"... a systematic, academic approach to the subject ... up-to-date ..." from THE LANCET Infectious Diseases (2005) 5: 681.
"This book fulfills its title, namely, it is a critical review of HIV chemotherapy. The book is timely and provides a unique blend of basic, preclinical, and clinical chapters which afford the reader with an up-to-date view of the virologic, immunologic, therapeutic, and molecular strategies toward development and implementation of potentially efficacious HIV therapy." from Microbe (2006).
"Overall, this is an outstanding small volume which is recommended for basic virologists, immunologists, and pathogenesis students of HIV, as well as teachers and clinicians involved in clinical care and teaching of HIV/AIDS. The editors and authors are to be commended for this valuable contribution." from Microbe (2006).
"Don't let the title fool you, this book gives a wide view of the state of the field in HIV treatment world-wide and includes some enticing discussions of potential targets and strategies on the horizon." from Aids Research and Therapy (2006) 3: 7.
"... a good source of information for investigators new to the field or those needing a quick source of information in areas tangential to their main focus." from Aids Research and Therapy (2006) 3: 7.
"... very readable ... very useful ..." from Clinical Infectious Diseases (2006) 43: 668-670.
"This text represents excellent value for money and is highly recommended for scientists, HIV clinicians and other health care professionals" from Aus. J. Med. Sci. (2006) 27: 152.
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