Caister Academic Press

HIV Chemotherapy: A Critical Review

Publisher: Caister Academic Press
Edited by: Salvatore T. Butera
National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Pages: x + 310
Publication date: September 2005
ISBN: 978-0-9542464-9-5
Price: GB £219 or US $250Buy book
Publication date: September 2005
ISBN: 978-1-913652-43-2
Price: US $319Buy ebook

Since the beginning of the AIDS pandemic in the early 1980's nearly 50 million people have been infected and over 16 million of those have died of AIDS. Combination anti-HIV therapy has dramatically reduced mortality rates and increased life expectancy in infected individuals. However it has not eradicated AIDS: the endemic is merely contained in industrialized nations and continues unabated in developing countries, e.g. Africa and parts of Asia. Since current anti-HIV drugs are virostatic rather than virotoxic, infected individuals must remain on drug therapy for life. This is a major problem since all of the existing anti-HIV drugs have side effects, some of which are serious and potentially fatal. In addition, the naturally occurring and extensive genetic variation found in HIV has led to the emergence of drug-resistant viruses. These challenges have prompted the urgent search for novel, molecular-based drugs and therapeutic strategies that target the different stages of viral infection of and interaction with the host.

This is a book aimed at the scientist in the research laboratory. Written by expert international authors, the book is an essential reference for scientists working on AIDS, HIV and other retroviruses. Expert AIDS researchers critically review every aspect of this highly topical subject. The opening chapters deal with the management of HIV infections and include a fascinating review of current molecular strategies to protect and strengthen the host immune system at the cellular level. Chapters 6 and 7 summarises the strategies required for the implementation of effective anti-HIV therapies in developing countries (90% of worldwide AIDS cases). Two excellent chapters (4 and 5) comprehensively review the genetics of viral drug resistance, and current drug-resistance testing technologies. The remaining chapters provide cutting-edge reviews of the latest viral and cellular targets for anti-HIV chemotherapy, the development of iRNA based therapeutics and molecular based strategies that target latent virus reservoirs in infected individuals.

Essential reading for scientists and clinicians working on AIDS, HIV, and other retroviruses as well as all health care professionals interested in expanding their current understanding of the subject.


"the book provides a useful attribute to all interested in HIV disease and its therapy ... When encountered on the actively employed bookshelves in the HIV / AIDS research laboratory it may be a frequently used source of information." from FEMS Immunol. Med. Microbiol. (2005) Nov/Dec.

"This excellent book is a comprehensive, critical review of aspects of HIV chemotherapy. ... an essential addition to any specialist library." from Microbiology Today (Feb 2006).

"... a systematic, academic approach to the subject ... up-to-date ..." from THE LANCET   Infectious Diseases (2005) 5: 681.

"This book fulfills its title, namely, it is a critical review of HIV chemotherapy. The book is timely and provides a unique blend of basic, preclinical, and clinical chapters which afford the reader with an up-to-date view of the virologic, immunologic, therapeutic, and molecular strategies toward development and implementation of potentially efficacious HIV therapy." from Microbe (2006).

"Overall, this is an outstanding small volume which is recommended for basic virologists, immunologists, and pathogenesis students of HIV, as well as teachers and clinicians involved in clinical care and teaching of HIV/AIDS. The editors and authors are to be commended for this valuable contribution." from Microbe (2006).

"Don't let the title fool you, this book gives a wide view of the state of the field in HIV treatment world-wide and includes some enticing discussions of potential targets and strategies on the horizon." from Aids Research and Therapy (2006) 3: 7.

"... a good source of information for investigators new to the field or those needing a quick source of information in areas tangential to their main focus." from Aids Research and Therapy (2006) 3: 7.

"... very readable ... very useful ..." from Clinical Infectious Diseases (2006) 43: 668-670.

"This text represents excellent value for money and is highly recommended for scientists, HIV clinicians and other health care professionals" from Aus. J. Med. Sci. (2006) 27: 152.

Table of contents
1. Progress in HIV Clinical Management
Kristen Marks and Roy M. Gulick
2. Immune Based Therapies in the Treatment of HIV-1 Infection
Sarah M. Wynne, Richard T. Davey and Jr.
3. Treatment Interruption Strategies for the Management of HIV-1 Infection
Marybeth Daucher and Mark Dybul
4. HIV-1 Mutation Rate: Implications for Drug Resistance and Viral Fitness
Miguel E. Quiñones-Mateu and Louis M. Mansky
5. HIV-1 Phenotypic and Genotypic Drug Resistance
Sarah Palmer
6. Implementing Antiretroviral Therapy in Developing Countries: Logistic Issues and Lessons Learned
John Nkengasong and Paul Weidle
7. Use of Antiretroviral Drugs to Prevent Mother-to-Child HIV-1 Transmission in High-Prevalence, Resource-Poor Settings
Marc Bulterys
8. Entry Inhibitors and Beyond
Cynthia A. Derdeyn and Eric Hunter
9. Cellular Factors as Targets for Anti-HIV-1 Chemotherapy
Masanori Baba
10. RNA Interference and HIV: From Here to Therapy
Premlata Shankar and Judy Lieberman
11. Clearance of Latent Reservoirs
David G. Brooks and Jerome A. Zack

How to buy this book

(EAN: 9780954246495 9781913652432 Subjects: [virology] [microbiology] [medical microbiology] [molecular microbiology] )