Genetically Modified Probiotics

Lactobacillus Genomics and Metabolic Engineering

Edited by: Sandra M. Ruzal

"the most relevant aspects of the more than 200 recognized species of the Lactobacillus genus" (ProtoView); "a useful, concise reference book" (Beneficial Microbes); "a good introduction to the current state of research ... it is a helpful review" (BIOSpektrum)

Genetically Modified Probiotics

Adapted from Lothar Steidler and Sabine Neirynck in Probiotics and Prebiotics: Scientific Aspects
Genetically Modified Probiotics: The intestinal microbiota is a key component of both the metabolism and immunity of humans and animals. It is therefore not surprising that proficient use of selected strains isolated from this ecosystem has led to a variety of microbiological products. These can be helpful in healthcare, especially for the management of digestive diseases and food-borne illnesses. The knowledge boom both in immunity and in the mechanisms by which infectious agents are active has led to the identification of key regulatory molecules and circuits that can drive health or disease. Through genetic engineering it became possible to fully express biologically active copies of such powerful molecules from food and commensal bacteria. Many aspects of genetically modified (GM) probiotics now lead to the belief that these have the potential to fill the existing gap in the probiotic activity spectrum. If designed carefully, and with absolute attention for biological safety in its broadest sense, the development of GM probiotics has the potential to revolutionize medicine.