The Spirochetes: Molecular and Cellular Biology
Publisher: Horizon Scientific Press
Editors: Milton H. Saier, Jr. University of California at San Diego, USA and Jorge García-Lara University of Georgia, USA
Publication date: July 2001
ISBN-10: 1-898486-27-1 (hbk)
ISBN-13: 978-1-898486-27-5 (hbk)
Pages: viii + 222
This book is devoted to the structural, molecular, physiological and evolutionary aspects of spirochetes. Written by leading scientists in the field, it summarizes important aspects of spirochetes as a phylogenetic group of organisms and also surveys key representative pathogenic spirochetes in greater detail.
The spirochetes include the causative agents of various important diseases, i.e. syphilis, periodontitis, Lyme disease, Leptospirosis and swine dysentery. This volume highlights in particular the recent advances in genetics, molecular biology and genomics in spirochete research.
Key Topics
• Phylogeny
• Motility
• Chemotaxis
• Bacteriophages
• Plasmids
• Genomics
• Genome analysis
• Genetic regulation
• Genetic manipulation
• DNA exchange
• Lipopolysaccharide biosynthesis
• Disease transmission
Chapter List
• Introduction to Spirochete Evolution, Genome Analyses and Physiology
M.H. Saier, Jr.
• Introduction to Genetic Development in Spirochetes
J. García-Lara
• Chapter 1. Phylogenetic Foundation of Spirochetes
B.J. Paster and F.E. Dewhirst
• Chapter 2. Gyrations, Rotations, Periplasmic Flagella: The Biology of Spirochete Motility Spirochete Periplasmic Flagella and Motility
C. Li, Md. A. Motaleb, M. Sal, S.F. Goldstein, and N.W. Charon
• Chapter 3. The Role of Chemotaxis in Pathogenesis of Spirochetes
R. Lux, A. Moter, and W. Shi
• Chapter 4. Bacteriophages of Borrelia burgdorferi and Other Spirochetes
C.H. Eggers, S. Casjens, and D.S. Samuels
• Chapter 5. The Genetics of Lipopolysaccharide Biosynthesis in Leptospira
D.M. Bulach, T. Kalambaheti, A. de la Peña-Moctezuma and B. Adler
• Chapter 6. Tick-Host Interactions in Spirochete Transmission
P.A. Nuttall, G.C. Paesen, C.H. Lawrie, V. Hajnicka, N. Fuchsberger, and H. Wang
• Chapter 7. Genome Analyses of Spirochetes: A Study of the ProteinStructures, Functions and Metabolic Pathways in Treponema pallidum and Borrelia burgdorferi
R. Das, H. Hegyi, and M. Gerstein
• Chapter 8. Whole Genome Analyses of Transporters in Spirochetes: Borrelia burgdorferi and Treponema pallidum
M.H. Saier, Jr. and I.T. Paulsen
• Chapter 9. Borrelia Genomes
S. Casjens
• Chapter 10. Repetition, Conservation, and Variation: the Multiple cp32 Plasmids of Borrelia Species
B. Stevenson, W.R. Zückert and D.R. Akins
• Chapter 11. Antibiotic Selective Markers and Spirochete Genetics
J.M. Hardham and E.L. Rosey
• Chapter 12. DNA Exchange and Insertional Inactivation in Spirochetes
K. Tilly, A.F. Elias, J.L. Bono, P. Stewart, and P. Rosa
• Chapter 13. Shuttle Vectors for Spirochetes
I. Saint Girons, B. Chi, and H. Kuramitsu
• Chapter 14. The Role of Genomics in Approaching the Study of Borrelia DNA Replication
J. García-Lara, M. Picardeau, B.J. Hinnebusch, W.M. Huang, and S. Casjens
• Chapter 15. Technological Advances in the Molecular Biology of Leptospira
R. Zuerner, D. Haake, B. Adler, and R. Segers
• Chapter 16. The Many Faces of Borrelia burgdorferi
J. Seshu and J.T. Skare
• Chapter 17. Transcriptional Regulation in Spirochetes of Medical Importance
K.J. Indest, R. Ramamoorthy, and M.T. Philipp
• Chapter 18. Biology of Treponema pallidum: Correlation of Functional Activities With Genome Sequence Data
Steven J. Norris, David L. Cox, and George M. Weinstock
• Index
(EAN: 9781898486275)
