Prions: Molecular and Cellular Biology
Publisher: Horizon Scientific Press
Editor: David A. Harris Washington University School of Medicine, St. Louis, Missouri, USA
Publication date: January 1999
ISBN-10: 1-898486-07-7 (hbk)
ISBN-13: 978-1-898486-07-7 (hbk)
Pages: vi + 218
This major new work contains reviews of recent and current research on the genetics, cell biology, and biochemistry of prions and prion diseases. The focus is on the cellular, biochemical, and genetic aspects of the unusual group of neurodegenerative disorders known as prion diseases, which were the subject of a recent Nobel Prize. The book is essential to all researchers working in the field and is recommended reading for scientists in other areas of biology and medicine. Contributions by internationally recognized experts cover a variety of experimental systems currently being used to understand the mechanisms underlying these fascinating and deadly diseases. The latest results and key theoretical issues are discussed, including the physical structure of prions, models of prion formation and pathogenesis, BSE and "new variant" Creutzfeldt-Jakob disease, yeast prions, and the strain pheneomenon.
"This book is absolutely the number one when it comes to having a good source of data on the molecular biology of prion disease......Each of the authors is one of the top in the field .....The book is a must for researchers ...." From:Airtime, UK
" Prions: Molecular and Cellular Biology provides an interesting cross section of current research on prions and prion diseases.... I found the book worthwhile......exceeded my expectations in terms of breadth of scope, clarity, insightful interpretation and thoroughness of the citations.......worthwhile reading for active prion researchers or molecular and cell biologists who have more than a passing interest in this subject." From:Trends in Microbiology
"... a very interesting and detailed introduction to molecular and cellular aspects of prion biology ... an impressive line-up of contributing authors ... " From:Trends in Genetics
"This book is a must for those of us working in the field ... I read it cover-to-cover in a weekend and it will remain a well-thumbed text in our lab." From:Microbiology Today
Features include:
• International reknown authors |
• Fully illustrated throughout |
• Comprehensive index |
• Multi-author |
• Exhaustive reference sections |
• Up-to-date |
• New variant CJD |
• Yeast prions |
• Latest results |
• Prion structure |
• Strain pheneomenon |
• Models of prion formation |
• Models of pathogenesis |
• PrP knockouts |
• NMR studies |
Authors Include:
Charles WeissmannAdriano Aguzzi
Byron Caughey
Bruce Chesebro
Rudi Glockshuber
Kurt Wüthrich
Suzette A. Priola
David A. Harris
Piero Parchi
Robert B. Petersen
Fabrizio Tagliavini
Bernardino Ghetti
Dominique Dormont
Reed B. Wickner
Chapter List
• Folding and three-dimensional NMR structure of the recombinant cellular prion protein from the mouse
Rudi Glockshuber, Simone Hornemann, Roland Riek, Martin Billeter, Gerhard Wider, Susanne Liemann, Ralph Zahn and Kurt Wüthrich
• Formation of protease-resistant prion protein in cell-free systems
Byron Caughey
• Expression of heterogeneous PrP molecules blocks formation of protease-resistant prion protein in vitro: Effect of amino acid mismatches at residue 138
Suzette A. Priola and Bruce Chesebro
• Cell biological studies of the prion protein
David A. Harris
• Inherited prion disease: molecular pathology and cell models
Piero Parchi, Sabina Capellari, Gianluigi Zanusso, Neena Singh, Pierluigi Gambetti and Robert B. Petersen
• The use of genetically modified mice in prion research
Charles Weissmann, Alex J. Raeber, Doron Shmerling, Antonio Cozzio, Eckhard Flechsig and Adriano Aguzzi
• Neurotoxicity and neuroinvasiveness of prions in neuroectodermal transplants
Adriano Aguzzi, Thomas Blättler, Michael A. Klein, Alex J. Räber, Ivan Hegyi, Rico Frigg, Charles Weissmann, and Sebastian Brandner
• Prion diseases: PrP peptides, pathogenesis and treatment perspectives
F. Tagliavini, M. Salmona, G. Forloni, P. Malesani, G. Giaccone, B. Canciani, R. McArthur, J. Lansen, P. Piccardo, S.R. Dlouhy, B. Ghetti, B. Frangione, F. Prelli, O. Bugiani
• The human genetic prion diseases
Katherine Young, Pedro Piccardo, Stephen Dlouhy, Orso Bugiani, Fabrizio Tagliavini, and Bernardino Ghetti
• Bovine spongiform encephalopathy and the new variant of Creutzfeldt-Jakob Disease
Dominique Dormont
• [URE3] and [PSI] are prions of yeast and evidence for new fungal prions.
Daniel C. Masison, Herman K. Edskes, Marie-Lise Maddelein, Kimberly L. Taylor and Reed B. Wickner
(EAN: 9781898486077)
