Helicobacter pylori: Molecular and Cellular Biology
Publisher: Horizon Scientific Press
Editor: Mark Achtman Berlin and Sebastian Suerbaum Würzburg, Germany
Publication date: February 2001
ISBN-10: 1-898486-25-5 (hbk)
ISBN-13: 978-1-898486-25-1 (hbk)
Pages: xii + 330
" ... a standard reference on this fascinating pathogen."
Charles Penn in Microbiology Today 29: 53 February 2002An awe-inspiring amount of knowledge has been acquired about Helicobacter pylori biology over the last decade. The diversity of approaches employed by scientists from different fields and the sheer numbers of publications produced make it difficult for even the most diligent reader to stay abreast of progress on this fascinating pathogen. In this book leading international scientists distil exciting findings from this vast body of literature to produce comprehensive and topical reviews on the molecular and cellular biology of H. pylori. The book begins with background chapters covering the history, taxonomy, and epidemiology of H. pylori infection, since these topics are paramount to an integrated understanding of H. pylori infection and associated diseases. It continues with chapters on host responses including immunity, apoptosis and animal models followed by chapters on virulence factors and vaccine development. The final section summarizes genome analyses, molecular typing and population genetics. Chapters are independent and can be read in any desired sequence.
The book will be extremely useful both to graduate students and to scientists not yet familiar with this area. In addition it will serve as a source of topical summaries of recent developments within this highly active area of research to Helicobacter experts. This book is essential reading for all researchers and clinicians working in the Helicobacter and related fields.
Chapter List:
Chapter 1: Helicobacter pylori: A Historical Overview
Drahoslava Pantoflickova and André L. Blum
Chapter 2: Taxonomy and Phylogeny of Helicobacter
James Versalovic and James G. Fox
Chapter 3: Epidemiologic Observations and Open Questions About Disease and Infection Caused by Helicobacter pylori
Roger A. Feldman
Chapter 4: Antigastric Autoimmunity and Pathology in Helicobacter pylori Gastritis
Gerhard Faller and Thomas Kirchner
Chapter 5: Cytokine Responses in Helicobacter pylori Infection
Jean E. Crabtree
Chapter 6: Role of Th1/Th2 Cells in H. pylori-induced Gastric Disease
Mario M. D'Elios and Gianfranco Del Prete
Chapter 7: Helicobacter pylori Induced Apoptosis
Siegfried Wagner and Winfried Beil
Chapter 8: Animal Models for Helicobacter pylori Gastritis
Kathryn A. Eaton
Chapter 9: Transgenic Mouse Models for Studying the Relationship between Helicobacter pylori Infection and Gastric Cancer
Per G. Falk, Andrew J. Syder, Janaki L.Guruge, Lars G. Engstrand, and Jeffrey I. Gordon
Chapter 10: Helicobacter pylori Urease
Harry L.T. Mobley
Chapter 11: Helicobacter Motility and Chemotaxis
Christine Josenhans and Sebastian Suerbaum
Chapter 12: Helicobacter pylori, An Adherent Pain in the Stomach
Markus Gerhard, Siiri Hirmo, Torkel Wadström, Halina Miller-Podraza, Susann Teneberg, Karl-Anders Karlsson, Ben Appelmelk, Stefan Odenbreit, Rainer Haas, Anna Arnqvist and Thomas Borén
Chapter13: Helicobacter pylori Lipopolysaccharides
Anthony P. Moran
Chapter 14: The cag Type IV Secretion System of Helicobacter pylori and CagA Intracellular Translocation
Markus Stein, Rino Rappuoli and Antonello Covacci
Chapter 15: Helicobacter pylori VacA Vacuolating Cytotoxin and HP-Nap Neutrophil Activating Protein
Cesare Montecucco, Emanuele Papini, Marina de Bernard, William G. Dundon, Mario Zoratti, Jean-Marc Reyrat, John L. Telford, Giuseppe del Giudice and Rino Rappuoli
Chapter 16: Development of a Helicobacter pylori Vaccine
Subhas Banerjee and Pierre Michetti
Chapter17: Comparative Analysis of the Helicobacter pylori Genomes
Richard A. Alm and Trevor J. Trust
Chapter 18: Molecular Typing of Helicobacter pylori
Leen-Jan van Doorn, Céu Figueiredo, and Wim Quint
Chapter 19: Population Structure of Helicobacter pylori and Other Pathogenic Bacterial Species
Mark Achtman
Index
