Caister Academic Press

Yersinia: Molecular and Cellular Biology

Publisher: Horizon Bioscience
Editors: Elisabeth Carniel and B. Joseph Hinnebusch Institut Pasteur, Paris, France and National Institutes of Health, Hamilton, USA
Publication date: October 2004
ISBN-10: 1-904933-06-8
ISBN-13: 978-1-904933-06-9
Pages: xii + 432

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Yersinia strains are important human pathogens causing diseases ranging from the deadly Plague (Yersinia pestis) to a relatively mild gastroenteritis (e.g. Y. enterocolitica and Y. pseudotuberculosis). Plague is currently classed as a re-emerging disease that is endemic in many parts of the world. Since Y. pestis is highly lethal (a very small number of bacilli are enough to kill someone in a matter of days) it could be used by bioterrorists as a formidable airborne adversary. This has provided the impetus for a renewed interest in Yersinia molecular and cellular biology. Written by the top Yersinia specialists this book reviews the genomics, molecular biology, cellular biology and evolution of these important organisms and comprehensively covers recent advances in the field. Topics include genetic diversity in Yersinia, quorum sensing, identification of virulence genes, regulation of virulence elements, superantigens, host invasion, host immune response, LPS structure and genetics, flagellar-dependent motility and protein secretion, iron and heme uptake systems, pathogenicity islands, the Yop effector proteins, plasminogen activator, F1 antigen, and the conjugative plasmid pVM82. Essential reading for everyone with an interest in Yersinia and recommended reading for other scientists working in microbial pathogenesis, microbial genomics and antimicrobial research.


"Essential reading for everyone with an interest in Yersinia" from CAB International (2005).

"The book consists of 19 well laid out chapters from expert Yersiniologists. It is accurate, thorough and for a book of this type, up-to-date. A credit to all contributors. This book is a must for Yersiniologists, but may also have wider appeal for researchers interested in biodefence, microbial genomics and the evolution of microbial virulence." from Microbiology Today (2005) August issue.

"This book is acknowledged as a comprehensive milestone in the rapidly changing study of Yersinia species. ... with over 400 pages and extensive references with each chapter, this book is obviously a reference textbook for graduate students, clinical microbiologists, and microbiologists involved not only in the study of Yersinia but also, more broadly, microbial pathogenesis and the evolution of pathogenesis." from Clin. Inf. Dis. (2005) 41: 1828-1829.

Chapter List:

Section I. Evolution and Genomics of Yersinia pestis.

Chapter 1.
The Yersinia pestis Chromosome
Nicholas R. Thomson and Julian Parkhill

Chapter 2.
Age, Descent and Genetic Diversity within Yersinia pestis
Mark Achtman

Chapter 3.
The Yersinia pestis-Specific Plasmids pFra and pPla
Luther E. Lindler

Chapter 4.
The Evolution of Flea-Borne Transmission in Yersinia pestis
B. Joseph Hinnebusch

Section II. Cellular Biology of Yersinia.

Chapter 5.
N-Acylhomoserine Lactone-Mediated Quorum Sensing in Yersinia
Steven Atkinson, R. Elizabeth Sockett, Miguel Cámara and Paul Williams

Chapter 6.
The Invasin Protein of Enteropathogenic Yersinia Species: Integrin Binding and Role in Gastrointestinal Diseases
Ka-Wing Wong, Penelope Barnes and Ralph R. Isberg

Chapter 7.
Transcriptional Regulation in Yersinia: An Update
Michael Marceau

Chapter 8.
Identification of Yersinia Genes Expressed During Host Infection
Andrew J. Darwin

Chapter 9.
Immune Responses to Yersinia
Erwin Bohn and Ingo B. Autenrieth

Chapter 10.
Superantigens of Yersinia pseudotuberculosis
Jun Abe

Section IIIA. Molecular Biology of Yersinia. Chromosome-Encoded Factors.

Chapter 11.
Lipopolysaccharides of Yersinia
Mikael Skurnik

Chapter 12.
Flagella: Organelles for Motility and Protein Secretion
Glenn M. Young

Chapter 13.
Iron and Heme Uptake Systems
Robert D. Perry and Jacqueline D. Fetherston

Chapter 14.
The High-Pathogenicity Island: A Broad-Host-Range Pathogenicity Island
Biliana Lesic and Elisabeth Carniel

Chapter 15.
YAPI, a New Pathogenicity Island in Enteropathogenic Yersiniae
François Collyn, Michael Marceau and Michel Simonet

Section IIIB. Molecular Biology of Yersinia. Plasmid-Encoded Factors.

Chapter 16.
The pYV Plasmid and the Ysc-Yop Type III Secretion System
Marie-Noëlle Marenne, Luís Jaime Mota and Guy R. Cornelis

Chapter 17.
The Plasminogen Activator Pla of Yersinia pestis: Localized Proteolysis and Systemic Spread
Timo K. Korhonen, Maini Kukkonen, Ritva Virkola, Hannu Lang, Marjo Suomalainen, Päivi Kyllönen and Kaarina Lähteenmäki

Chapter 18.
Structure Assembly and Applications of the Polymeric F1 Antigen of Yersinia pestis
Sheila MacIntyre, Stefan D. Knight and Laura J. Fooks

Chapter 19.
pVM82: A Conjugative Plasmid of the Enteric Yersinia that Contributes to Pathogenicity
George B. Smirnov

How to buy this book

(EAN: 9781904933069)