Caister Academic Press

Microbial Toxins: Molecular and Cellular Biology

Publisher: Horizon Bioscience
Editor: Thomas Proft Department of Molecular Medicine & Pathology, School of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
Publication date: 01 Feb 2005
ISBN-10: 1-904933-08-4
ISBN-13: 978-1-904933-08-3
Pages: x + 568

In recent years, enormous progress has been made in our understanding of the molecular and cellular biology of microbial toxins. This has important implications for the development of novel therapeutics such as antimicrobial agents, antitoxins, vaccines etc., and is particularly relevant for toxins that have the potential for use in bioterrorism. In addition, toxin research contributes to the understanding of the structures, functions and metabolism of eukaryotic cells in health and disease.

Written by leading toxinologists, this topical book comprehensively reviews the molecular and cellular biology of the most important microbial toxins with a focus on recent advances in the field. Topics include: toxin ADP-ribosylation of proteins, toxin inhibition of protein synthesis, modulation of actin cytoskeleton, cytolethal distending toxins, cell-damaging/pore-forming toxins, clostridial neurotoxins, toxins of the immune system, streptococcal and staphylococcal toxins, anthrax toxins, Shiga toxin, Yersinia toxin, mycotoxins, and the regulation of toxin expression. The book concludes with a chapter on the potential of microbial toxins in bioterrorism.

Essential reading for everyone with an interest in microbial toxins and recommended reading for other scientists with an interest in biodefence, microbial pathogenesis, microbial genomics, antimicrobial agents, and vaccine development.

Key Features:

* Detailed Discussions of Cutting Edge Topics
* Expert International Authors
* Fully Up-To-Date
* Broad Coverage
* Comprehensive Reference Section


"This multiauthor book provides comprehensive and current knowledge of the molecular and cellular biology of important microbial toxins." by CAB International (2005).

"provides a comprehensive, authoritative and up-to-date review on microbial toxins. ... I would recommend this book to anyone interested in these fascinating molecules." by Microbiology Today (Feb 2006).

"This text will be useful for researchers who are either new to the field of microbial toxins or who have followed the field for years ... " from The Quarterly Review of Biology (2006) 81: 64.

Chapter List:

Chapter 1
Joseph E. Alouf

Chapter 2
Activation of Secondary Messenger Pathways by ADP-Ribosylation of G-proteins
Michael Jobling and Randall K. Holmes

Chapter 3
Microbial Toxins That Modulate the Actin Cytoskeleton
Jianjun Sun, Klaus Aktories, and Joseph T. Barbieri

Chapter 4
The Cytolethal Distending Toxin
Carol Pickett and Robert B. Lee

Chapter 5
Toxins That Interfere with Protein Synthesis
Diana Marra Oram and Randall K. Holmes

Chapter 6
Cell-damaging/Pore-forming Toxins
Robert J. C. Gilbert

Chapter 7
Clostridial Neurotoxins: Mechanism of Action of Tetanus and Botulinum Neurotoxins
Ornella Rossetto and Cesare Montecucco

Chapter 8
Superantigens - Microbial Toxins That Target the Immune System
Thomas Proft, Birgit Schrage, and John D. Fraser

Chapter 9
The Role of Toxins in Invasive Streptococcal Disease
Hugh H. Russell and Shiranee Sriskandan

Chapter 10
Toxins in Staphylococcus aureus Pathogenesis
Gilles Prévost

Chapter 11
Pathogenesis of Bacillus anthracis: The Role of Anthrax Toxins
Yogendra Singh, Xudong Liang, and Nicholas S. Duesbery

Chapter 12
Clostridial Gas Gangrene: Clinical Correlations, Microbial Virulence Factors, and Molecular Mechanisms of Pathogenesis
Dennis L. Stevens, and Amy E. Bryant

Chapter 13
Contribution of Shiga Toxin (Verotoxin) to the Pathogenesis of Shigella and Escherichia coli.
Patty Tam and Clifford Lingwood

Chapter 14
Yersinia Ysc-Yop System: The Role in Pathogenesis
Indira Basu and Joan Miquel Balada-Llasat

Chapter 15
Bacteriocins Associated with Cytotoxicity for Eukaryote Cells
Philip A. Wescombe, Nicholas C. K. Heng, Ralph W. Jack, and John R. Tagg

Chapter 16
Mycotoxins and Human Disease
Ruth A. Etzel

Chapter 17
Host Cell Penetration and Trafficking of Protein Toxins
Kirsten Sandvig, Silje U. Lauvrak, and Bo van Deurs

Chapter 18
Regulation of Bacterial Toxin Expression
Nathan Shankar and Michael S. Gilmore

Chapter 19
Modification and Improvement of Live Bacterial Vaccines by the Use of Bacterial Cytolysins
Guido Dietrich and Werner Goebel

Chapter 20
Microbial Toxins as Potential Tools in Bioterrorism
Stuart C. Clarke

(EAN: 9781904933083)