Caister Academic Press

Tuberculosis: The Microbe Host Interface

Publisher: Horizon Bioscience
Editor: Larry S. Schlesinger The Ohio State University, Columbus, Ohio 43210, USA
Lucy DesJardin of the University of Iowa, Iowa City, IA 52242, USA
Publication date: January 2004
ISBN-10: 0-9545232-1-0
ISBN-13: 978-0-9545232-1-3
Pages: x plus 281

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M. tuberculosis remains one of the most successful human pathogens known. The causative agent of tuberculosis, it also has an unique ability to persist for years in the infected, apparently healthy host. This dormant organism can be reactivated years, even decades later to cause tuberculosis. Knowledge regarding the interaction of M. tuberculosis with the host is fundamental to understanding the pathogenesis; leading eventually to the development of strategies for the prevention and control of infection and disease.

By integrating genetic, microbiologic, immunologic, and cell biologic approaches to elucidate pathogenesis, penetrating new insights into the interaction of M. tuberculosis with the host have emerged. This book reviews the most important state-of-the-art approaches currently used to study microbe-host interactions and highlights emerging methodologies. Strategies to analyze the following topics are included: mycobacterial entry, growth, and gene expression in macrophages; analysis of post-phagocytic events; analysis of signaling in infected macrophage; the acquired immune response; newer animal- and non animal-models systems; latency; and the epidemiology of M. tuberculosis infections.

Key Features:

* Detailed Discussions of Cutting Edge Topics
* Expert International Authors
* Useful Index
* Up-To-Date
* Broad Coverage


"I loved this book; it provided exactly what I wanted. .... Highly recommended." from Microbiology Today (2004) 31: 99.

"I highly recommend that you read (this book).... a state-of-the-art study ... interesting reading for microbiologists, molecular biologists, and clinicians." from International Microbiology (2004) 7: 79.

"This book presents state-of-the-art knowledge of the interface of M. tuberculosis with the host ... Microbiologists, molecular biologists, clinicians, and pharmaceutical and biotechnology scientists will find this source of current knowledge on tuberculosis pathogenesis upgrading and inspiring" from Vet. Human Toxicol. (2004) 46(5): 293.

"The contents of this book are most timely considering the worldwide reappearance of TB ... Recommended" from E-STREAMS (2005) Vol 8 no. 3 March 2005.

"This volume will be a good starting place for neophytes and a useful summation of the current literature for more seasoned mycobacteriologists." from The Quarterly Review of Biology (2005) 80: 148.

Chapter List:

Chapter 1
Mycobacterial Entry and Growth Using in vitro Macrophage Models
Zahra Toossi and Larry S. Schlesinger

Chapter 2
Analysis of Post-Phagocytic events
Daniel L. Clemens

Chapter 3
Analysis of Macrophage Signaling Following M. tuberculosis Infection
David Kusner

Chapter 4
The Acquired Immune Response to M. tuberculosis
W. Henry Boom

Chapter 5
New In Vitro Models of Mycobacterial Pathogenesis
Frederick D. Quinn, Luiz E. Bermudez and Kristin A Birkness

Chapter 6
Animal Models in the Analysis of Pathogenesis
Andrea M. Cooper

Chapter 7
Analysis of Mycobacterium tuberculosis Gene Expression in the Human Host
Josephine E. Clark-Curtiss and Lucy E. DesJardin

Chapter 8
Analysis of Latency
John Chan and JoAnne Flynn

Chapter 9
Molecular Epidemiology: Clinical Utility, Public Health Implication, and Relevance to Pathogenesis
Peter F. Barnes and M.Donald Cave

How to buy this book

(EAN: 9780954523213)