Caister Academic Press

Molecular Biology of Streptococci

Publisher: Horizon Bioscience
Editors: Regine M. Hakenbeck1 and Singh Chhatwal2
1University of Kaiserslautern, Department of Microbiology, Kaiserslautern 6766363, Germany and 2Helmholtz Centre for Infection Research, D-38124 Braunschweig, Germany
Publication date: 01 April 2007
ISBN: 978-1-904933-32-8 (hardback)
ISBN: 978-1-904933-37-3 (ebook)
Pages: xiv + 578

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The genus Streptococcus is huge and encompasses a large variety of human and animal pathogenic and commensal bacteria. It is not known why some species are virulent and others not, and why even within one species, the virulence potential varies. These and other key questions are addressed in this timely book which draws on the recent advances in streptococcal genomics to provide an up-to-date coherent picture of the molecular and cellular biology of streptococci. With contributions from internationally renowned streptococcal researchers, this comprehensive book reviews all of the important topics. The book is divided into three sections: Streptococcus pneumoniae, Streptococcus spp. (group A and group B streptococci, oral streptococci and others), and Methods. Topics include: genetic transformation in S. pneumoniae, biologically active S. pneumoniae peptides, the pneumococcal cell wall, the capsular polysaccharides, virulence factors and adhesion proteins, genetic regulation of virulence, genome-wide screening for essential S. pneumoniae genes, molecular epidemiology, penicillin resistance, and much more. An important and useful feature of this book is the methods section. This contains information on a number of key streptococcal molecular genetic techniques which will be invaluable to the reader. Essential reading for all streptococcal genome, moecular biology researchers and a recommended text for scientists and medical microbiologists working on bacterial genomics and pathogenesis.

Chapter List:

Part I: Streptococcus pneumoniae

Chapter 1: Genetic Transformation in Streptococcus pneumoniae: Strategies for Genome Modification
Donald A. Morrison

Chapter 2: Biologically Active Peptides in Streptococci
Ola Johnsborg, Trinelise Blomqvist, Mogens Kilian and Leiv Sigve Håvarstein

Chapter 3: Competence in Streptococcus pneumoniae: What is it For?
Sébastien GuiraL, Miriam Moscoso, Adilia Dagkessamanskaia, and Jean-Pierre Claverys

Chapter 4: Structure and Biosynthesis of the Pneumococcal Cell Wall
Waldemar Vollmer

Chapter 5: Pneumococcal Capsular Polysaccharides: Biosynthesis and Regulation
James C. Paton and Judy K. Morona

Chapter 6: Pneumococcal Virulence Factors and Adhesion Proteins Targeting the Host
Sven Hammerschmidt

Chapter 7: Genetic Regulation of Virulence in Streptococcus pneumoniae
Tim J. Mitchell and Gavin K. Paterson

Chapter 8: Genome-wide Screening for Essential Genes of Streptococcus pneumoniae: Current Approaches and Future Opportunities
Peter Burghout, Hester J. Bootsma, and Peter W.M. Hermans

Chapter 9: Streptococcus pneumoniae: From Colonization and Infection Towards Prevention Strategies
D. Bogaert, R. de Groot, and P.W.M. Hermans

Chapter 10: Molecular Epidemiology and Mechanisms for Antibiotic Resistance in Streptococcus pneumoniae
Birgitta Henriques Normark

Chapter 11: Mechanisms of Penicillin Resistance in Streptococcus pneumoniae: Targets, Gene Transfer and Mutations
Dalia Denapaite, Fang Chi, Patrick Maurer, Oliver Nolte, and Regine Hakenbeck

Part II: Streptococcus spp.

Chapter 12: Virulence Factors and Their Regulation in Group A Streptococcus
Kadaba S. Sriprakash and David J. McMillan

Chapter 13: Streptococcal Peptide Transmembrane Transport: Description of Transport Systems and Biological Consequences
Michael G. Caparon, Bert Poolman, and Andreas Podbielski

Chapter 14: Gene Expression and Tagging of Streptococcal Proteins
Jason N. Cole, Martina L. Sanderson-Smith, Amanda J. Cork, Anna Henningham, Feildhlim Conlan, Marie Ranson, Jason D. McArthur and Mark J. Walker

Chapter 15: Molecular Pathogenesis of Group B Streptococcal Infections
Amanda L. Jones and Craig E. Rubens

Chapter 16: Oral Streptococci: Commensals and Opportunistic Pathogens
Charles F. Schachtele, Angela Nobbs, Yongshu Zhang, Massimo Costalonga, and Mark C. Herzberg

Chapter 17: Virulence Mechanisms of Streptococcus suis
Laurentiu Benga and Peter Valentin-Weigand

Chapter 18: Adhesion and Invasion of Streptococci in Eukaryotic Cells
D. Patric Nitsche-Schmitz, Manfred Rohde, and Gursharan S. Chhatwal

Part III: Methods

Chapter 19: In Vitro Mariner Mutagenesis of Streptococcus pneumoniae: Tools and Traps
Marc Prudhomme, Andrew Camilli, and Jean-Pierre Claverys

Chapter 20: There Will be a Light: The Use of luc Transcriptional Fusions in Living Pneumococcal Cells
Marc Prudhomme and Jean-Pierre Claverys

Chapter 21: Protocol for Conjugal Transfer of Genetic Elements in Streptococcus pneumoniae
Francesco Iannelli, Catiuscia Orienti, and Gianni Pozzi

Chapter 22: Preparation and Analysis of Pneumococcal Murein (Peptidoglycan)
Waldemar Vollmer

Chapter 23: Detection of Penicillin-Binding Proteins
Jens Rutschmann, Patrick Maurer, and Regine Hakenbeck

Chapter 24: Approaches to Elucidate Pneumococci-host Interactions
Sven Hammerschmidt

Chapter 25: Mouse Models of Pneumococcal Infection
Tim J. Mitchell and Gavin K. Paterson

Chapter 26: Protocol for Pulsed-field Gel Electrophoresis for Streptococcus pneumoniae
Raquel Sá-Leão and Hermínia de Lencastre

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(EAN: 9781904933328)