Hepatitis C Viruses: Genomes and Molecular Biology
Publisher: Horizon Bioscience
Editor: Seng-Lai Tan Lilly Research Laboratories, Indianapolis, USA
Publication date: August 2006
ISBN-10: 1-904933-20-3
ISBN-13: 978-1-904933-20-5
Pages: x + 470 (plus 6 page colour plate section)
Hepatitis C is recognized as one of the most important new diseases afflicting man. The discovery, diagnosis and initial treatments of hepatitis C virus (HCV) infection are all perfect examples of the increasing impact molecular biology is currently having on disease management throughout the globe. Both the intensity and breadth of HCV research are growing at a remarkable pace and exciting new discoveries are becoming almost commonplace.
This book reviews the current state of progress in HCV molecular biology and discusses the questions that are currently facing molecular investigators. The chapters provide in-depth reviews of the most critical areas of HCV molecular research today. Topics covered include: the HCV genome and life cycle, the HCV core protein, glycoproteins, protease and serine protease, helicase, regulator proteins, replicon systems, regulation of host defense and adaptive immunity, vaccine design, and cell culture systems.
The internationally renowned authors review and discuss the most recent aspects of HCV infection, replication and molecular biology. An essential book for anyone studying HCV!
Chapter List:
Introduction
Hepatitis C
David R. Gretch
Chapter 1
HCV Genome and Life Cycle
Stéphane Chevaliez and Jean-Michel Pawlotsky
Chapter 2
HCV 5' and 3'UTR: When Translation Meets Replication
Stephanie T. Shi and Michael M. C. Lai
Chapter 3
Assemble and Interact: Pleiotropic Functions of the HCV Core Protein
Stephen J. Polyak, Kevin C. Klein, Ikuo Shoji, Tatsuo Miyamura and Jaisri R. Lingappa
Chapter 4
HCV Glycoproteins: Assembly of a Functional E1-E2 Heterodimer
Muriel Lavie, Anne Goffard and Jean Dubuisson
Chapter 5
HCV NS2/3 Protease
Sarah Welbourn and Arnim Pause
Chapter 6
HCV NS3-4A Serine Protease
Chao Lin
Chapter 7
HCV Helicase: Structure, Function, and Inhibition
David N. Frick
Chapter 8
HCV NS4B: from Obscurity to Central Stage
Ella H. Sklan and Jeffrey S. Glenn
Chapter 9
HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
Yupeng He, Kirk A. Staschke and Seng-Lai Tan
Chapter 10
Biochemical Activities of the HCV NS5B RNA-Dependent RNA Polymerase
C. T. Ranjith-Kumar and C. Cheng Kao
Chapter 11
HCV Replicon Systems
Keril J. Blight and Elizabeth A. Norgard
Chapter 12
Animal Models for HCV Study
Linda B. Couto and Alexander A. Kolykhalov
Chapter 13
HCV Regulation of Host Defense
Spencer Carney and Michael Gale Jr.
Chapter 14
Regulation of Adaptive Immunity by HCV
Xiao-Song He
Chapter 15
Recombinant Vesicular Stomatitis Virus (VSV) and Other Strategies in HCV Vaccine Designs and Immunotherapy
Ayaz M. Majid and Glen N. Barber
Chapter 16
Development of an Infectious HCV Cell Culture System
Takaji Wakita and Takanobu Kato
(EAN: 9781904933205)
