Caister Academic Press

Molecular Biology of the Flavivirus

Publisher: Horizon Bioscience
Editor: Matthias Kalitzky and Peter Borowski University Hospital Hamburg-Eppendorf, and Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany
Publication date: October 2006
ISBN: 978-1-904933-22-9 (hardback)
ISBN: 978-1-904933-47-2 (ebook)
Pages: xii + 380

How to Order . Download PDF of entire book

Flaviviruses constitute a family of linear, single-stranded RNA(+) viruses. They cause approximately 70 different diseases which have a major impact on national economies and health authorities worldwide. With contribution from internationally acclaimed authors such as Ernest Gould and Hubert Blum, this book reviews the most significant cutting edge discoveries in the flavivirus field. Aspects of molecular biology common to flaviviruses are explored in depth. Topics include the evolution and function of flavivirus RNA, flavivirus replication, laboratory diagnosis and vaccine development. Individual chapters are devoted to the molecular biology of yellow fever virus, dengue virus, Japanese encephalitis virus, and hepatitis virus C virus. Essential reading for all flavivirus researchers and a recommended text for all virology laboratories.


"focus on the latest knowledge about this family ... the book mainly concentrates on molecular aspects" from Human Vaccines (2007)

"beneficial for any scientist or clinician studying human viral pathogens" from Doodys (2007)

Chapter List:

Chapter 1
The Molecular Biology of Yellow Fever Virus
Beate M. Kümmerer

Chapter 2
Title: Taxonomy and Evolution of the Flaviviridae
Ernest A. Gould and Tamara S. Gritsun

Chapter 3
Origin, Evolution and Function of Flavivirus RNA in Untranslated and Coding Regions: Implications for Virus Transmission
T. S. Gritsun, A. Tuplin and E. A. Gould

Chapter 4
Cis and Trans-acting Determinants of Flaviviridae Replication
Sven-Erik Behrens and Olaf Isken

Chapter 5
A New Approach to Dengue Epidemiology. Sequential Infection and ADE Hypothesis: The Story of a Dogma
Xavier Deparis

Chapter 6
Functional Role of prM Glycoprotein in Dengue Virus Replication
Nopporn Sittisombut, Poonsook Keelapang and Prida Malasit

Chapter 7
Diagnosis of Dengue Virus Infection
María G. Guzmán, Delfina Rosario, and Gustavo Kourí

Chapter 8
Japanese Encephalitis Virus: Molecular Biology and Vaccine Development
Sang-Im Yun and Young-Min Lee

Chapter 9
Evolution, Epidemiology and Control of the Japanese Encephalitis Virus
Ma Shao-Ping and Makino Yoshihiro

Chapter 10
Maturation and Assembly of Hepatitis C Virus Core Protein
Tetsuro Suzuki and Ryosuke Suzuki

Chapter 11
Molecular Virology and Pathogenesis of Hepatitis C
Darius Moradpour and Hubert E. Blum

Chapter 12
Treatment of HCV-related Liver Diseases and Prevention of Hepatocellular Carcinoma
Kyuichi Tanikawa

Chapter 13
A New Perspective in The Pathophysiology Of Hepatitis C Virus (HCV) Infection: Interaction of the NS3 Protein of HCV With Serine-/Threonine-Specific Protein Kinases
Matthias Kalitzky, Holger Rohde, and Peter Borowski

How to buy this book

(EAN: 9781904933229)