Caister Academic Press

Dictyostelium Genomics

Publisher: Horizon Bioscience
Editors: William F. Loomis and Adam Kuspa University of California San Diego, La Jolla, California and Baylor College of Medicine, Houston Texas
Publication date: August 2005
ISBN-10: 1-904933-13-0
ISBN-13: 978-1-904933-13-7
Pages: xii + 304

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Dictyostelium discoideum is a model eukaryotic organism for basic biomedical research in cell and developmental biology and for the functional analysis of sequenced genes. The organism has unique advantages for studying fundamental cellular processes such as cytokinesis, motility, phagocytosis, chemotaxis, signal transduction, cell sorting, pattern formation, and cell-type determination. This book, written to coincide with the publication of the genome sequence of Dictyostelium, introduces the post-genomic era and focuses on the important aspects of Dictyostelium genomics. Leading experts in the field have contributed chapters on genomic mapping and sequencing, databases, multigene families, regulation of gene expression, signal transduction, the microfilament system, the GTPase superfamily, the kinome, glycosyltransferase genomics, and whole-genome functional analysis. Essential reading for all researchers and graduates with an interest in Dictyostelium or developmental and cellular biology and a recommended text for anyone involved in genomics research.


"This is a gold mine of information for those interested in genomics research. A major strength of this book is that it provides up-to-date information, based on solid interpretation of the genome sequence. Each author delves into a different topic in protein biochemistry (from microfilaments to glycosyltransferases). The book is clearly written, carefully edited, and easy to read. It is filled with esoteric, yet fascinating facts. I enjoyed reading about the life cycle of this primitive eukaryote in the first chapter .... I recommend this book highly for all those interested in genomics research and developmental biology." from Bruce A Fenderson, Thomas Jefferson University Doody's Book Reviews (2006)

Chapter List:

Chapter 1
Mapping and Sequencing the Dictyostelium Genome
William F. Loomis

Chapter 2
dictyBase: Using the Genome to Organize Dictyostelium Biology
Rex L. Chisholm

Chapter 3
Metabolic Pathways
Samuel H. Payne

Chapter 4
Multigene Families of Dictyostelium
Christophe Anjard

Chapter 5
Components of the Dictyostelium Gene Expression Regulatory Machinery
Gad Shaulsky and Eryong Huang

Chapter 6
Signal Transduction via G-Protein-Coupled Receptors, Trimeric G Proteins, and RGS Proteins
Dale Hereld

Chapter 7
The Microfilament System of Dictyostelium discoideum
Francisco Rivero and Ludwig Eichinger

Chapter 8
The Small GTPase Superfamily
Gerald Weeks, Pascale Gaudet and Robert H. Insall

Chapter 9
The Dictyostelium Kinome: Protein Kinase Signaling Pathways that Regulate Growth and Development
Alan R. Kimmel

Chapter 10
Glycosyltransferase Genomics in Dictyostelium discoideum
Christopher M. West, Hanke van der Wel, Pedro M. Coutinho and Bernard Henrissat

Chapter 11
How Many Protein Encoding Genes Does Dictyostelium discoideum Have?
Rolf M. Olsen

Chapter 12
Whole-Genome Functional Analyses in Dictyostelium
Adam Kuspa

How to buy this book

(EAN: 9781904933137)