Caister Academic Press

Brucella: Molecular and Cellular Biology

Publisher: Horizon Bioscience
Editor: Ignacio López-Goñi and Ignacio Moriyón Universidad de Navarra, Pamplona, Spain
Publication date: 01 November 2004
ISBN-10: 1-904933-04-1
ISBN-13: 978-1-904933-04-5
Pages: xiv + 432

How to Order

Publication of the complete genome sequences of several different Brucella species has provided researchers with the opportunity to take a more directed approach to study this organism's physiology, virulence, and genetic diversity. In this book highly acclaimed Brucella scientists comprehensively review all of the most important advances in the Brucella post-genomic era providing for the first time a coherent picture of Brucella molecular and cellular biology. The book opens with chapters that focus on the development of molecular diagnostic tools and these are followed by chapters on genetic evolution and its relationship to pathogenicity. Other topics include Brucella comparative genomics and proteomics, analysis of the structure, biosynthesis and biology of glucans and lipopolysaccharides, pathogenicity, approaches to vaccine development, bacterium-host interactions, immune response, and much more. Essential reading for everyone with an interest in Brucella and brucellosis and recommended reading for the wider body of scientists with an interest in microbial diagnostics, microbial pathogenesis, cellular microbiology and immunology, and vaccine development.

Key Features:

* Detailed Discussions of Cutting Edge Topics
* Expert International Authors
* Fully Up-To-Date
* Broad Coverage
* Comprehensive Reference Section


"... provides a timely, up-to-date review of the current knowledge of Brucella, linking post-genomic data with accepted dogma and highlighting current and persistent questions pondered by researchers today." from Microbiology Today (2005) August issue.

"This is a very useful volume for anyone interested in developments in brucellosis research." from Clinical Infectious Diseases (2006) 42: 439 February issue.

Chapter List:


Chapter 1
DNA Polymorphism and Taxonomy of Brucella Species

Axel Cloeckaert and Nieves Vizcaino

Chapter 2
Molecular Diagnostics of Animal Brucellosis: A Review of PCR-Based Assays and Approaches

Betsy J. Bricker

Chapter 3
Polymerase Chain Reaction: A Powerful New Approach for the Diagnosis of Human Brucellosis

Juan D. Colmenero, María I. Queipo-Ortuño and Pilar Morata

Chapter 4
A Brucella melitensis Genomic Database

Xavier De Bolle, Christophe Lambert, Eric Depiereux and Jean-Jacques Letesson

Chapter 5
Comparative Genomics of Brucella melitensis, B. suis, and B. abortus

Shirley M. Halling, Cynthia Gibas and Stephen Boyle

Chapter 6
Comparative Proteomics of Brucellae Species

Vito G. DelVecchio and Cesar V. Mujer

Chapter 7
Brucella Virulence: A Matter of Control

Jean-Jaques Letesson and Xavier De Bolle

Chapter 8
Brucella Lipopolysaccharide: Structure, Biosynthesis and Genetics

Maite Iriarte, David González, Rose M. Delrue, Daniel Monreal, Raquel Conde, Ignacio López-Goñi, Jean-Jacques Letesson, and Ignacio Moriyón

Chapter 9
Brucella Cyclic b-1,2-Glucans: Structure, Biosynthesis, Biological Activities and Role in Virulence

Nora Iñón de Iannino and Rodolfo A. Ugalde

Chapter 10
The Brucella bvrS/bvrR and Related Two-Component Regulatory Systems of the a-2 Proteobacteria: Common Regulatory Strategies of Animal and Plant Pathogens and Endosymbionts.

Ignacio López-Goñi, Lorea Manterola and Shen Q. Pan

Chapter 11
Erythritol Metabolism and Virulence in Brucella

Juan M. García-Lobo and Félix Sangari García

Chapter 12
Iron Metabolism in Brucella

R. Martin Roop II, Bryan H. Bellaire, Eric Anderson and James T. Paulley

Chapter 13
Brucella Interaction with Membrane Lipids of the Host Cell

Masahisa Watarai

Chapter 14
Invasion, Intracellular Trafficking and Replication of Brucella Organisms in Professional and Non-Professional Phagocytes

Edgardo Moreno and Jean-Pierre Gorvel

Chapter 15
The Intramacrophagic Environment of Brucella spp. and Their Replicative Niche

Véronique Jubier-Maurin, Séverine Loisel, Jean-Pierre Liautard, and Stephan Köhler

Chapter 16
Host Cellular Immune Responses Against Brucella spp. Evaluated Using the Mouse Model

Cynthia L. Baldwin and Radhika Goenka

Chapter 17
Development of New Brucella Vaccines by Molecular Methods

David L. Hoover, Mikeljon P. Nikolich, Mina J. Izadjoo, Richard H. Borschel, and Apurba K. Bhattacharjee

Chapter 18
Alternative Ovine Brucellosis Vaccine: Experiences with Drug Delivery Systems

Carlos Gamazo, Maite Estevan, Maribel Murillo, M. Jesús Grilló, Clara M. Marín, Montserrat Barberán, M. Mar Goñi, José M. Blasco, and Juan M. Irache

How to buy this book

(EAN: 9781904933045)