Caister Academic Press

Acanthamoeba: Biology and Pathogenesis

Author: Naveed Khan
Published: 2009   ISBN: 978-1-904455-43-1
Everything that is known about Acanthamoeba is critically reviewed and divided into easy-to-follow sections. The current state of research on genomics, molecular and cellular biology, life cycles, geographical distribution, role in ecosystem, morphology, motility, phylogenetics, genotyping, metabolism, regulation of morphogenesis, host-parasite interactions, the molecular and immunological basis of pathogenesis, methods of transmission, epidemiology, clinical manifestation, diagnosis, treatment, new target development and drug resistance, and much more. read more ...

Figure from: Acanthamoeba Biology and Pathogenesis

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Section B. Figure 14. A. Acanthamoeba cysts under phase-contrast microscope. i) Non-nutrient agar plates exhibiting Acanthamoeba cysts. ii) Acanthamoeba cysts were collected from non-nutrient agar plates using PBS and observed under the phase-contrast microscope. Note cysts formed clusters in PBS, X400. B. Acanthamoeba trophozoites on non-nutrient agar plates observed under phase-contrast microscope. Note the characteristic contract vacuole in Acanthamoeba trophozoites, X400. C. Acanthamoeba trophozoite binding to glass cover slips observed under scanning electron microscope. Note large number of acanthopodia on the surface of Acanthamoeba trophozoites belonging to the T4 genotype. D. Acanthamoeba binding to corneal epithelial cells. Acanthamoeba castellanii (T4 isolate) were incubated with corneal epithelial cells, followed by several washes and observed under scanning electron microscope. Note that parasites were able to exhibit binding to the host cells and binding was mediated by acanthopodia. A is amoeba, E is corneal epithelial cell. Bar = 10 micrometers.

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