Caister Academic Press

Malaria Parasites: Genomes and Molecular Biology

Publisher: Caister Academic Press
Edited by: A.P. Waters and C.J. Janse
Leiden University Medical Centre, Leiden, The Netherlands
Pages: xii + 546
Publication date: March 2004
ISBN: 978-0-9542464-6-4
Price: GB £219 or US $250Buy book
Publication date: March 2004
ISBN: 978-1-913652-44-9
Price: US $319Buy ebook
Malaria Parasites book
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The completion of the Plasmodium falciparum genome sequence in late 2002 hearlded a new era in malaria research. The search began in earnest for new drugs and vaccines to combat malaria, a disease which afflicts up to 500 million people worldwide and is responsible for the deaths of more than one million people each year. The new genomic data is aiding a greater understanding of the living parasite and its interaction with the insect vector and human host.

In this book internationally renown experts provide up-to-date reviews of the most important aspects of post-genomic malaria research. Topics covered include: the P. falciparum genome and model parasites, bioinformatics and genome databases, microsatellite analysis, analysis of chromosome structure, cell cycle to RNA polymerase I and II mediated gene expression, role of the nuclear genome, the parasite surface and cell biology, and much more.

The book is essential reading for all parasitologists and scientists with an interest in malaria.


"the most important aspects of post-genomic malaria research" from BookNews Inc.

"edited by one of the most respected teams in parasitology ... its depth and coverage are second to none. ... could not be more timely ... the parasitic biology of Plasmodium is revealed in all its molecular glory as never before. Buy it." from Nature Genetics (2004) 36(6): 545.

"the book's 16 Chapters provide an excellent and informative snapshot of our current understanding of the parasite from a genomic perspective. ...edited and illustrated to a very high standard." from The Biochemist (2004).

"This excellent book will help researchers progress from information overload to exploitation and application. ... There is an impressive array of knowledge here." from Microbiology Today (2004) 31: 199.

Table of contents
1. The Genome of Plasmodium falciparum
Neil Hall and Malcolm Gardner
2. The Genome of Model Malaria Parasites, and Comparative Genomics
Jane Carlton, Joana Silva and Neil Hall
3. Getting the Most out of Bioinformatics Resources
Jessica C. Kissinger and David S. Roos
4. Manipulating the Plasmodium Genome
Teresa Gil Carvalho and Robert Ménard
5. Toxoplasma gondii a Model Organism for the Apicomplexans?
Dominique Soldati and Markus Meissner
6. Microsatellite Markers and Population Genetics in Plasmodium falciparum
Deirdre Joy, Jianbing Mu, and Xin-zhuan Su
7. Chromosome Structure and Dynamics of Plasmodium Subtelomeres
Artur Scherf, Luisa M. Figueiredo and Lúcio H. Freitas-Junior
8. Gene Expression
Kirk W Deitsch
9. Regulation of rRNA Transcription and Processing During the Plasmodium Life Cycle
Thomas F. McCutchan, Rosalinda van Spaendonk, Chris Janse, Jun Fang, and Andrew P. Waters
10. Cell Cycle Control in Plasmodium falciparum: A Genomics Perspective
Christian Doerig and Debopam Chakrabarti
11. The Apicoplast
Ross F. Waller and Geoff I. McFadden
12. The Surface of the Plasmodium falciparum-infected Erythrocyte
Joseph D. Smith and Alister G. Craig
13. Merozoite Cell Biology
Agnieszka E. Topolska, Lina Wang, Casilda G. Black, and Ross L. Coppel
14. Sexual Development of Malaria Parasites
C.J. Janse and A.P. Waters
15. Ookinete Cell Biology
R.E. Sinden, Y.I.H. Alavi, G.A. Butcher, J.T. Dessens, J.D. Raine, and H.E. Trueman
16. Molecular and Cellular Biology of Chloroquine Resistance in Plasmodium falciparum
Karena L. Waller, Sylvia Lee and David A. Fidock

How to buy this book

(EAN: 9780954246464 9781913652449 Subjects: [microbiology] [genomics] [medical microbiology] [molecular microbiology] )