Enteropathogenic Yersinia: Antibiotic Resistance and Susceptibility of Yersinia enterocolitica and Yersinia pseudotuberculosis
Jeanette N. Pham
from: Yersinia: Systems Biology and Control (Edited by: Elisabeth Carniel and B. Joseph Hinnebusch). Caister Academic Press, U.K. (2012)
Yersinia enterocolitica and Yersinia pseudotuberculosis, the two enteropathogenic species of the genus Yersinia, are poles apart in their natural resistance to β-lactam antibiotics. While Yersinia pseudotuberculosis, as a species, is susceptible to all antibiotics used in the treatment of Gram-negative infections, Y. enterocolitica susceptibility to β-lactam antibiotics varies. Due to the presence of chromosomal β-lactamases, Y. enterocolitica are inherently resistant to ampicillin and cephalothin. The consistent pattern of β-lactam antibiotic susceptibility of each bioserotype and subgroup within a bioserotype is explained by the production or the lack of production of two chromosomally encoded β-lactamases. One is the non inducible broad spectrum enzyme A, a β-lactamase of molecular class A, and the other one is enzyme B, an inducible cephalosporinase of molecular class C. Fluoroquinolones alone or in combination with a third generation cephalosporin are very effective at treating severe infections caused by Y. pseudotuberculosis or Y. enteterocolitica read more ...