Type I interferon production by viruses
Kazuhide Onoguchi, Kiyohiro Takahasi, Mitsutoshi Yoneyama, and Takashi Fujita
from: Viruses and Interferon: Current Research (Edited by: Karen Mossman). Caister Academic Press, U.K. (2011)
Type I interferon (IFN) is produced in variety of tissues in the body. It has been known that viral infection efficiently induces type I IFN. Bacterial endotoxin and double stranded (ds) RNA are representative non-viral inducers. Recent works revealed that cellular receptors for Pathogen Associated Molecular Patterns (PAMPs) are responsible for triggering IFN production. In the case of virus infection, RNA molecules encoded by viruses are sensed by the PAMPs receptors. Different viruses preferentially activate different sensor molecules. Current knowledge on virus- or RNA pathogen-specificity as well as structure-function relationship of RNA sensing is summarized. Furthermore, numerous signaling adaptors are reported to participate in the regulation of IFN gene activation read more ...