Caister Academic Press

Antibiotic Resistance in Vibrio cholerae

T. Ramamurthy
from: Vibrio cholerae: Genomics and Molecular Biology (Edited by: Shah M. Faruque and G. Balakrish Nair). Caister Academic Press, U.K. (2008)

Abstract

Antimicrobial resistance has become a major medical and public health problem as it has direct link with the disease management. Vibrio cholerae, the cholera causing pathogen is increasingly developing resistance towards many antimicrobials used for the treatment of diarrhoea. However, the pattern of resistance differs from country to country. The well-known factor responsible for development and spread of resistance is injudicious use of antimicrobial agents, which is directly related to the stimulation of several mechanisms of resistance. In V. cholerae, several resistance mechanisms such as plasmid encoded resistance, mutation in the quinolones resistance determining regions, integrons, efflux pumps and SXT constins have been established. Considering the importance of drug resistance, quick diagnostic assay methods are available for the identification of multidrug resistant (MDR) V. cholerae. Many new generation antimicrobials were discovered, which are effective against V. cholerae in the in vitro studies. The resistance pattern of V. cholerae to several antimicrobials are not always uniform as it depends on the source of isolation. In some of the recent findings it established that vibrios can act as reservoirs of antimicrobial resistance as cross-spread is common in in vitro studies. Promotion of indigenous drugs should be considered in the future and studied in detail for their efficacy read more ...
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