Caister Academic Press

The Molecular Role of the Polar Outer Membrane Protein IcsA (VirG) in Shigella Actin-based Motility

Anuradha Janakiraman
from: Shigella: Molecular and Cellular Biology (Edited by: William D. Picking and Wendy L. Picking). Caister Academic Press, U.K. (2016) Pages: 169-192.


Central to the cytosolic life-cycle of the Gram-negative bacterial pathogen, Shigella, is the ability to polymerize host cell actin at the bacterial pole to generate actin comet tails. The actin tails generate a propulsive force that aid in intracellular and intercellular bacterial motility and is an essential feature of Shigella virulence. The bacterial outer membrane protein, IcsA (VirG), plays a critical role in Shigella actin-based motility. Here we review key findings and discuss recent developments that aid in our understanding of the polar localization of IcsA and IcsA-mediated Shigella actin-tail assembly read more ...
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