Coordination of RNA Editing with Other RNA Processes in Kinetoplastid Mitochondria
Jorge Cruz-Reyes and Laurie K. Read
from: RNA Editing: Current Research and Future Trends (Edited by: Stefan Maas). Caister Academic Press, U.K. (2013)
The extraordinary RNA editing by U insertion and U deletion in mitochondrial mRNAs is arguably the best characterized process in kinetoplastids. However, much less is known about ancilliary factors of the editing multiprotein enzyme core. This enzyme architecture and basic catalysis guided by small non-coding gRNAs have enjoyed central stage, compared to other aspects in the biology of editing substrates, from biogenesis to translation. Many mRNAs and thousands of gRNAs are undoubtedly targeted by numerous factors that regulate unwinding, annealing, stability, assembly into editing enzymes, and translation. Recent years have seen a virtual explosion in the discovery of editing accessory factors. This chapter discusses the progress in this area, and frames a working model whereby the editing machinery is functionally and physically linked to pre and post editing events through a dynamic higher-order network of protein and RNA interactions read more ...