Virus-host Protein Interactions of Plant-adapted Rhabdoviruses.
Michael M. Goodin and Byoung-Eun Min
from: Rhabdoviruses: Molecular Taxonomy, Evolution, Genomics, Ecology, Host-Vector Interactions, Cytopathology and Control (Edited by: Ralf G. Dietzgen and Ivan V. Kuzmin). Caister Academic Press, U.K. (2012)
Rhabdoviruses belonging to the genus Nucleorhabdovirus are unique in that they have not only adapted to replication in both plant and invertebrate cells but they are nucleotrophic as well. Beyond their roles as plant pathogens, these viruses also serve as probes to provide insights into plant nuclear biology. Using data gained from studies with Sonchus yellow net virus and Potato yellow dwarf virus, this review will describe protein interaction and membrane dynamics in virus-infected cells, with particular emphasis on relating these findings to the mechanism of cell-to-cell movement. To date, five host factors have been implicated in the process of moving nucleocapsids from infected cells into adjacent ones. These host factors, in concert with several virus-encoded proteins, are thought to form a cytoplasmic complex that migrates from nuclei on microtubules and membranes towards the plasmodesmata where they dock onto plasmodesmata-localized protein 1. Prior to moving cell-to-cell, these viruses induce dramatic changes in nuclear membranes, particularly the inner nuclear membrane, during establishment of a nuclear viroplasm, were nascent nucleocapsids form on ring-shaped protein complexes before accumulating in the perinuclear space read more ...