Morphology, Genome Organization, Transcription and Replication of Rhabdoviruses
Ralf G. Dietzgen
from: Rhabdoviruses: Molecular Taxonomy, Evolution, Genomics, Ecology, Host-Vector Interactions, Cytopathology and Control (Edited by: Ralf G. Dietzgen and Ivan V. Kuzmin). Caister Academic Press, U.K. (2012)
Rhabdoviruses have large enveloped virions with bullet-shaped or bacilliform morphology. They are composed of an infectious nucleocapsid enveloped by a host-derived lipid membrane containing glycoprotein spikes. Their genomes consist of a non-segmented, negative-sense ssRNA which encodes at least five structural proteins. The replication cycle of all rhabdoviruses involves the same general steps. Following cell entry and uncoating, the nucleocapsid that contains all the components necessary for early transcription is released into the cytoplasm of the infected cell. The different viral genes are transcribed and proteins translated, followed by genome replication, encapsidation and budding from cell membranes read more ...