Caister Academic Press

Naegleria fowleri: biology and pathogenesis

Ruqaiyyah Siddiqui and Naveed A Khan
from: Protozoan Parasitism: From Omics to Prevention and Control (Edited by: Luis Miguel de Pablos Torró and Jacob-Lorenzo Morales). Caister Academic Press, U.K. (2018) Pages: 131-156.


Naegleria fowleri is a free-living protist pathogen, that can infect the central nervous system to produce fatal primary amoebic meningoencephaltis (PAM). The amoeba enters through the nasal cavity via contaminated water and reaches the the brain via olfactory neuroepithelial route to produce infection within days and almost always results in death (Symmers, 1969). A complete knowledge of this parasite, how it lives in the environment, and produces diseases is crucial for the rational development of preventative and therapeutic strategies read more ...
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