African Swine Fever Virus
E. Arabyan, A. Kotsinyan, A. Hakobyan and Hovakim Zakaryan
from: Porcine Viruses: From Pathogenesis to Strategies for Control (Edited by: Hovakim Zakaryan). Caister Academic Press, U.K. (2019) Pages: 1-20.
African swine fever virus (ASFV) is a large DNA virus belonging to the family Asfarviridae. It is the causative agent of an acute haemorrhagic fever in domestic pigs and wild boar with high fatality rates, up to 100%, in the acute forms. The disease is currently present in Africa and Europe, where it causes a high socio-economic impact. In this chapter we have addressed different aspects of ASFV including the biology of virus which is relevant for understanding the viral disease. We have also discussed the pathological changes caused by highly and low virulent ASFV strains. Finally, this chapter addresses the current approaches for ASFV diagnosis, as well as presents an overview of research efforts toward the development of effective vaccines during the past decades. As an alternative to vaccine development, the current state in antiviral research is also presented read more ...