Non-coding RNAs, Epigenomics and Complexity in Human Cells
Fabricio F. Costa
from: Non-coding RNAs and Epigenetic Regulation of Gene Expression: Drivers of Natural Selection (Edited by: Kevin V. Morris). Caister Academic Press, U.K. (2012)
During the past two decades, new technologies in molecular biology and human genetics have enabled the discovery of different types of non-coding RNAs. Non-coding RNAs are RNA transcripts that have no apparent protein product. These molecules have been grouped in different classes such as microRNAs, small RNAs and long RNAs (lncRNAs) according to their size and function. LncRNAs have been strongly associated to epigenetic mechanisms in different cell types. Conceivably, they have been described as an essential part of the human epigenome. In this chapter, examples of lncRNAs and their function will be presented. A historical perspective on the impact of lncRNAs in epigenetic mechanisms, human disease and evolution will be also discussed read more ...