Caister Academic Press

Biochemistry of Mo-Nitrogenase

John W. Peters, Eric S. Boyd, Trinity Hamilton and Luis M. Rubio
from: Nitrogen Cycling in Bacteria: Molecular Analysis (Edited by: James W. B. Moir). Caister Academic Press, U.K. (2011)

Abstract

The large majority of biological nitrogen fixation occurs by the activity of Mo-nitrogenase. Mo-nitrogenase is found in a wide variety of bacteria and some Archaea and is a complex two component enzyme that contains multiple metal-containing prosthetic groups. The biochemistry of nitrogenase has a rich history and the enzyme is a model system for examining more general processes in biology such as electron transfer, metal-cofactor assembly, and even nucleotide dependent signal transduction. In addition, studies examining nitrogenase has pushed the envelope in terms of the practical application of various spectroscopic methods. This chapter treats the historical perspective and development of key advances in our understanding of the biochemistry of Mo-nitrogenase from its infancy and early beginnings in the 1960s to the state of the field today read more ...
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