Interactions of Pathogenic Neisseria with Neutrophils in the Context of Host Immunity
Alison K. Criss
from: Pathogenic Neisseria: Genomics, Molecular Biology and Disease Intervention (Edited by: John K. Davies and Charlene M. Kahler). Caister Academic Press, U.K. (2014)
The pathogenic Neisseria species, N. gonorrhoeae and N. meningitidis, avoid clearance by cells of the human immune system in order to persist in their obligate human hosts. This chapter will explore the mechanisms used by the pathogenic Neisseria to subvert the antimicrobial actions of neutrophils. These mechanisms include manipulating phagocytosis, modulating the oxidative burst, preventing granule release, defending against toxic neutrophil products, and extending neutrophil lifespan. Interactions between Neisseria and other innate immune cells (macrophages, dendritic cells) and with components of adaptive immunity (T and B cells) will be examined in the context of the Neisseria- and neutrophil-driven inflammatory response read more ...