Neisseria Biofilms: Biology, Formation and Role in Pathogenesis
Michael A. Apicella
from: Pathogenic Neisseria: Genomics, Molecular Biology and Disease Intervention (Edited by: John K. Davies and Charlene M. Kahler). Caister Academic Press, U.K. (2014)
Both N. gonorrhoeae and N. meningitidis can form biofilms on the surfaces they inhabit. In both it is important for sustaining asymptomatic colonization and for dispersal of the organism. In the gonococcus, it is most probably a major factor resulting in the frequent emergence of antibiotic resistance as new therapies are applied. Both use eDNA as a matrix for the biofilm. The meningococcus and the gonococcus both have the ability to produce an autoinducer-2 like molecule but at present very little is known about the role of quorum sensing in their biology read more ...