Genomics and Reference Libraries
Keith A. Jolley and Martin C. J. Maiden
from: Pathogenic Neisseria: Genomics, Molecular Biology and Disease Intervention (Edited by: John K. Davies and Charlene M. Kahler). Caister Academic Press, U.K. (2014)
Whole genome sequencing is now available at a cost that means it will very soon become a routine tool in epidemiology and public health. There is a challenge, however, in making sense of the vast amount of information encoded in a bacterial genome and in being able to relate this to the large collection of legacy data that exists for many bacterial species. The Neisseria community has lead the way in embracing nucleotide sequencing for typing and epidemiology and is at the forefront of the push to apply whole genome sequencing to research and public health. In this chapter we review the platform and databases hosting Neisseria allelic diversity data and discuss how they can be used to extract relevant information and perform comparative genomics read more ...