Caister Academic Press

Conclusions and Future Studies

from: Brain-eating Amoebae: Biology and Pathogenesis of Naegleria fowleri (Author: Ruqaiyyah Siddiqui, Ibne Karim M. Ali, Jennifer R. Cope and Naveed Ahmed Khan ). Caister Academic Press, U.K. (2016) Pages: 183-192.


The diagnosis of N. fowleri infections is not straightforward and treatment is problematic. Further research is needed for prevention, pathogenesis and therapy and in particular for the development of rapid, cost-effective, and non-invasive assays for early diagnosis. Moreover, epidemiology studies are needed to determine the true burden of N. fowleri infection, both in humans and animals, and whether disease patterns differ around the world. There is a need to determine the effect of environmental factors, demographic factors, socioeconomic factors, in the spread, transmission, and prevalence of the parasite, as well as host susceptibility in contracting N. fowleri infection. The precise molecular mechanisms underlying N. fowleri pathogenesis and the role of inflammation and immune response need to be elucidated, as well as the understanding of mechanisms of flagellation, encystation, excystation, and associated metabolic pathways. In addition, there is a need for improvement of educational efforts to raise awareness among the public as well as the medical community (neurologists, physicians) of this devastating infection read more ...
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