The Host-damage Response to N. fowleri
from: Brain-eating Amoebae: Biology and Pathogenesis of Naegleria fowleri (Author: Ruqaiyyah Siddiqui, Ibne Karim M. Ali, Jennifer R. Cope and Naveed Ahmed Khan ). Caister Academic Press, U.K. (2016) Pages: 83-100.
Primary amoebic meningoencephalitis is a product of N. fowleri virulence factors and collateral damage from the host immune responses. Immune-mediated host damage is particularly important within the central nervous system, where the immune responses may exacerbate cerebral edema and neurological damage, leading to coma and death. Given the challenges associated with the availability of effective antimicrobial chemotherapy, here we discuss existing knowledge of the role of immune response to N. fowleri. Consideration of the underlying mechanisms of host responses can provide critical insights into host damage that can be exploited to develop adjunctive therapies to improve disease outcome read more ...