Future of Molecular Diagnostics: The Example of Infectious Diseases
Eoin Clancy, Kate Reddington, Thomas Barry, Jim Huggett and Justin O'Grady
from: Molecular Diagnostics: Current Research and Applications (Edited by: Jim Huggett and Justin O'Grady). Caister Academic Press, U.K. (2014)
Advances in molecular diagnostics technologies offer clinicians improved infectious diseases tests for use in a hospital setting with regards to specificity, sensitivity and turn-around time to results. These advances have the potential to contribute in a positive way to patient care owing to improved decision making on optimal therapeutic approaches. Such advances may be used independent of traditional culture based methods, or in some instances complementing culture. In this chapter we review a number of emerging technologies which can be used for both targeted and non-targeted molecular diagnostics in the clinical setting which may play a central role in the future including fully integrated "sample in - result out" nucleic acid based tests, digital PCR, mass spectrometry and next generation sequencing read more ...