Injection Schemes for Microchip-based Analysis Systems
Michelle W. Li, Amanda L. Bowen, Nicholas G. Batz and R. Scott Martin
from: Lab-on-a-Chip Technology (Vol. 1): Fabrication and Microfluidics (Edited by: Keith E. Herold and Avraham Rasooly). Caister Academic Press, U.K. (2009)
A review with 64 references that describes and gives experimental details for the injection modes commonly used in microchip-based electrophoresis and flow injection analysis. The two most frequently used electrokinetic injection techniques, pinched and gated injection, are first reviewed. In the context of electrokinetic injections, a description on how the detection mode can influence the method of injection is given, as detection modes such as electrochemistry have the requirement that no potential can be applied to the reservoir where the electrodes reside. Additionally, work we have published using elastomeric valves to couple hydrodynamic injections to microchip electrophoresis is detailed. Finally, the methods that can be used to perform reproducible and discrete injections for microchip-based flow injection analysis are discussed read more ...