The Bovine Lentiviruses: Pathogenesis and Cell Tropism
Moira Desport and Sandy McLachlan
from: Lentiviruses and Macrophages: Molecular and Cellular Interactions (Edited by: Moira Desport). Caister Academic Press, U.K. (2010)
Infections with the bovine lentiviruses, bovine immunodeficiency virus (BIV) or Jembrana disease virus (JDV) represent the extremes of lentivirus induced disease. BIV has a broad cell tropism and causes a mild lymphoproliferative disorder with low viral titres and no reproducible disease sequelae. JDV has a more restricted cell tropism than BIV and infects Bali cattle in Indonesia, replicating to high viral titres during an acute disease period characterized by lymph node enlargement, leucopaenia and high rectal temperatures. The similarities and differences between these two genetically and antigenically closely related viruses and between other lentiviruses will be reviewed in this chapter with particular regard to their cell tropism, pathogenesis and genetic composition read more ...