Cellular Defence of the Leishmania Parasite
Sanchita Das and Chandrima Shaha
from: Molecular Biology of Kinetoplastid Parasites (Edited by: Hemanta K. Majumder). Caister Academic Press, U.K. (2018) Pages: 67-80.
One of the major defence approaches of host against a pathogen is to generate ROS (Reactive Oxygen Species) and RNS (Reactive Nitrogen Species) to eliminate infections. How the pathogen overcomes this stress response is the key to successful invasion and sustenance of infection.Leishmania spp. is accountable for the disease Leishmaniasis that manifests itself in a cutaneous or a visceral form and survives within macrophage phagosomes, the very compartments that are supposed to eliminate them. Leishmania spp. lacks catalases but has evolved several important defensive armories. These include, the peroxiredoxins, thiols, ascorbate peroxidase, selenoproteins, kinases and phosphatases. Available data on the variety of defence systems are discussed read more ...