Replication, Partitioning, Segregation, and Cell Division in Helicobacter pylori
Teruko Nakazawa and Hiroaki Takeuchi
from: Helicobacter pylori: Molecular Genetics and Cellular Biology (Edited by: Yoshio Yamaoka). Caister Academic Press, U.K. (2008)
Chromosome replication and cell division are essential steps for bacterial proliferation. Recent studies in Escherichia coli and some other bacteria have emerged important insights on the whole process. The complete genome sequences of three strains of Helicobacter pylori revealed that homologs of most genes involved in replication and segregation are present, suggesting that the basic mechanisms are common. However, some orthologs for cell division are missing in H. pylori possibly because of its unique niche in gastric mucus as well as the life style. Analysis of the replication machinery of H. pylori has started very recently. The replication origin oriC, the initiator protein DnaA, and the replication helicase DnaB was identified. In addition, the ParABS system for chromosome partitioning was identified. FtsK-dif system for chromosome segregation and FtsZ-ring system for cell division might be functioning in H. pylori like in many other bacteria although further studies are required to elucidate the process read more ...