Horizontal Gene Transfer and Recombination in the Evolution of Antibiotic Resistance Genes
Miriam Barlow, Jared Caywood, Serena Lai, Joshua Finley and Chad Swanlund
from: Horizontal Gene Transfer in Microorganisms (Edited by: M. Pilar Francino). Caister Academic Press, U.K. (2012)
Recombination is a mechanism that leads to variation in antibiotic resistance genes. We review its importance in the recently emerged nosocomial pathogen Acinetobacter baumannii, where Horizontal Gene Transfer (HGT) and recombination are major sources of variation for resistance phenotypes. We also present our results focusing on the plasmid borne genes of blaCTX-M, ampC and qac. These results show that random point mutations are not the only major source of variants among the plasmid borne genes, but that homologous recombination is a major contributor of gene variants that can likewise add and remove resistance phenotypes from bacterial populations. Further studies of HGT and recombination are therefore important to determine how their effects can be manipulated to control the occurrence of resistance read more ...