Laboratory Diagnostic Methods to Support the Surveillance and Control of Foot-and-mouth Disease
Anna Ludi, Valerie Mioulet, Nick J. Knowles and Donald P. King
from: Foot-and-Mouth Disease Virus: Current Research and Emerging Trends (Edited by: Francisco Sobrino and Esteban Domingo). Caister Academic Press, U.K. (2017) Pages: 275-286.
Foot-and-mouth disease (FMD) infects cloven-hoofed livestock and is globally one of the most widespread epizootic animal diseases. FMD is difficult and expensive to control since the causative virus FMD virus (FMDV) is highly contagious and spreads rapidly through susceptible animals. FMD remains endemic and impacts upon the rural livelihoods in many countries in Africa and Asia, from where it can spread to cause sporadic outbreaks in countries that are normally free from disease, such as the recent episodes that have occurred in East Asia (South Korea and Japan) and Europe (Bulgaria). These outbreaks reinforce the concerns about how readily the disease can pass across international borders, and stimulate the development and improvement of new assays for the detection and characterisation of FMDV. Focusing on the recent revolution in molecular and sequencing technologies, this chapter reviews the range of approaches that are increasingly being employed by FMD Reference Laboratories to support national programmes and regional roadmaps for the identification, surveillance, control and eradication of FMD read more ...