Stem-specific Broadly Neutralizing Antibodies of Influenza Virus Hemagglutinin
Fengyun Ni and Qinghua Wang
from: Influenza: Current Research (Edited by: Qinghua Wang and Yizhi Jane Tao). Caister Academic Press, U.K. (2016) Pages: 1-16.
The past few years have witnessed a substantial advance in identifying novel antibodies that target conserved structural elements on influenza hemagglutinin, the receptor-binding site and the stem domain, thus revived the hope for universal antibody. This chapter reviews the isolation of stem-specific bnAbs, the structural basis of bnAb-mediated virus neutralization, and the novel strategies for eliciting bnAbs in vivo read more ...