Quantitative and Qualitative Characterization of the CD8+ T cell Response to Influenza Virus Infection
Nicole L. La Gruta, Peter C. Doherty1 and 2
from: Influenza Virology: Current Topics (Edited by: Yoshihiro Kawaoka). Caister Academic Press, U.K. (2006)
The CD8+ T cell response to influenza virus infection is critical for the efficient clearance of viral infection. The advent of tetramer staining has, over the last 5-10 years, enabled accurate quantitation of the epitope specific CD8+ T cell response to influenza virus infection, and has revealed much about immunodominance hierarchies and the kinetics of individual epitope specific responses. More recently, particular interest has been paid to the quality of CD8+ T cell responses, such as cytokine production and cytolytic ability, since T cell function must be a key factor in determining the efficacy of the response. Here, we describe recent advances in the characterization of both magnitude and quality of the CD8+ T cell response to influenza virus infection. These studies may also serve as a model to elucidate general mechanisms of CD8+ T cell-mediated viral clearance read more ...