Dendritic Cells: Induction and Regulation of the Adaptive Immune Response to Influenza Virus Infection
Kevin L. Legge and Thomas J. Braciale
from: Influenza Virology: Current Topics (Edited by: Yoshihiro Kawaoka). Caister Academic Press, U.K. (2006)
Clearance of respiratory viruses, like influenza virus, from the respiratory tract requires induction of an adaptive immune response. Initiation of adaptive immunity to foreign pathogens, like influenza virus, is thought to be mediated by dendritic cells. Dendritic cells perform this function by first sensing the invader in peripheral sites, maturing, and then migrating to the draining regional lymph nodes where they interact with and activate na•ve T and B cells. In this review, we will highlight and discuss what role dendritic cells may play in the induction and regulation of the adaptive immune response to pulmonary influenza virus infections, and how the interaction of influenza virus with dendritic cells may influence the shape of the developing adaptive immune response read more ...