Host Responses During Mild and Severe Dengue
Mark Schreiber, Joel Leong, and Martin Hibberd
from: Molecular Virology and Control of Flaviviruses (Edited by: Pei-Yong Shi). Caister Academic Press, U.K. (2012)
Dengue fever is an acute viral infection that can produce a wide spectrum of disease outcomes in patients, ranging from mild or even asymptomatic fever to severe manifestations including hemorrhagic fever and shock. With the incidence of the severe forms increasing in most tropical countries as well as an overall increase in dengue incidence, dengue fever is becoming a significant burden on the health systems of affected countries. In this review, we examine the clinical definitions and presentation of mild and severe dengue as well as recent research into the underlying molecular mechanisms of the differential host response. Finally, we will examine how host responses from the early phase of the disease might be useful as biomarkers for predicting the eventual disease outcome read more ...